2-CHLORO-5-CARBOXYPHENYLBORONIC ACID

2-CHLORO-5-CARBOXYPHENYLBORONIC ACID - Names and Identifiers

Name	2-Chloro-5-carboxyphenylboronic acid
Synonyms	3-BORONO-4-CHLOROBENZOIC ACID 5-Carboxy-2-Chlorophenylboroni 2-CHLORO-5-CARBOXYPHENYLBORONIC ACID 2-Chloro-5-carboxyphenylboronic acid 5-CARBOXY-2-CHLOROPHENYLBORONIC ACID 5-CARBOXY-2-CHLOROBENZENEBORONIC ACID 5-Carboxy-2-chlorobenzeneboronic acid (5-Carboxy-2-chlorophenyl)boronic acid 5-CARBOXY-2-CHLOROBENZENEBORONIC ACID 98 4-chloro-3-(dihydroxyboranyl)benzoic acid
CAS	913835-75-3
InChI	InChI=1/C7H6BClO4/c9-6-2-1-4(7(10)11)3-5(6)8(12)13/h1-3,12-13H,(H,10,11)

2-CHLORO-5-CARBOXYPHENYLBORONIC ACID - Physico-chemical Properties

Molecular Formula	C7H6BClO4
Molar Mass	200.38
Density	1.55±0.1 g/cm3(Predicted)
Melting Point	228-244
Boling Point	462.5±55.0 °C(Predicted)
Flash Point	233.5°C
Solubility	soluble in Methanol
Vapor Presure	2.36E-09mmHg at 25°C
Appearance	Crystallization
Color	White to Almost white
pKa	3.98±0.10(Predicted)
Storage Condition	Inert atmosphere,2-8°C
Refractive Index	1.603

2-CHLORO-5-CARBOXYPHENYLBORONIC ACID - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	41 - Risk of serious damage to eyes
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection.
Hazard Note	Irritant/Keep Cold
Hazard Class	IRRITANT, KEEP COLD

2-CHLORO-5-CARBOXYPHENYLBORONIC ACID - Introduction

Acid (acid) is an organic compound with the following properties:

1. Appearance: Colorless crystalline solid.
2. Solubility: Soluble in some organic solvents, such as dimethyl sulfoxide, dimethylformamide, etc.
3. Stability: relatively stable at room temperature.

The main use of this compound is as a reagent for organic synthesis and catalytic reactions. It can be used to generate palladium catalysts for cross-coupling reactions such as Suzuki coupling and Stille coupling. In addition, it can also be used to construct carbon-carbon bonds of organic compounds such as alcohols, aldehydes and ketones. It also has certain applications in drug synthesis and pesticide synthesis.

The method for preparing the phenol acid is relatively simple, usually by reacting 2-chlorophenylboronic acid with sodium carbonate. Specific synthesis methods can be found in the literature or by referring to the synthesis manual.

Regarding safety information, this compound is generally not fatal to human health, but certain safe handling measures are still required. When handling this compound, it is recommended to wear appropriate protective equipment, such as glasses, gloves, etc. In addition, direct inhalation of its dust or contact with the skin should be avoided. If ingested or inhaled, seek medical help immediately.

Last Update：2024-04-09 20:52:54